MILK THISTLE PHYTO PLUS
100 op. - 500 mg/op.
Silybum marianum (fruits) dry extract 250 mg (2% silymarin)
Silybum marianum (fruits) phytosome dry extract 250 mg (33% silymarin)
PHYSIOLOGICAL EFFECT: promotes the digestive, hepatic and purifying functions of the body and the metabolism of carbohydrates. Antioxidant
The presence of phosphatidylcholine derived from soy lecithin led us to request from the manufacturer a certified declaration of the non-presence of GMOs which was promptly provided to us.
Unfortunately, silymarin and silybin have poor intestinal absorption, which limits their benefits. For this reason, many studies on the hepatoprotective properties of flavolignans have used complexed phospholipid ingredients made via phytosome technology, such as phytosome silymarin.
As demonstrated by comparative pharmacokinetic studies, phospholipid silymarin represents the most absorbable oral form of silybin known. In rats, after oral administration of 200 mg/kg of silybin, plasma levels of silybin and its conjugated metabolites were below the limit of analytical detection, while, after oral administration of phospholipid silymarin (200 mg/kg as silybin) Plasma levels of silybin (free and total) were easily measurable, being well absorbed when in phytosome form.
In another study in rats, Silybine given as the phospholipid silymarin at 200 mg/kg was detectable in plasma within minutes, peaked after 1 hour, and its plasma levels remained elevated for more than 6 hours. The value of free silybin in the blood after taking the phospholipid silymarin was more than 400% compared to taking uncomplexed silymarin. Phospholipid silymarin rapidly reaches the liver, passes through liver cells and appears in the bile within 2 hours. The amount of silybin reaching the bile with the phospholipid silymarin was at least 6.5 times higher than that from uncomplexed silybin administered as silymarin.
The pharmacokinetics of the phospholipid silymarin in healthy human subjects showed that complexation with phosphatidylcholine improved the oral bioavailability of silybin 4.6-fold compared to uncomplexed silymarin, presumably due to facilitated passage through the gastrointestinal mucosa.
PHYTOSOMES
The soy phospholipid complexes with plant active ingredients that are poorly soluble in water and lipids give rise to phytosomes. In phytosomes the active ingredient forms hydrogen and/or polar bonds with the phospholipid. Phosphatidylcholine lends itself to this task, in fact it has a negatively polarized head and a positively polarized one, which bind to the complementary polar groups of the plant substances.
The bioavailability of several herbal active ingredients can be irregular and poor due to limited gastrointestinal absorption and pH instability of the digestive tract. The poor absorption may be due to the size of the molecule of the vegetal principle which prevents its diffusion and to the poor or no miscibility in lipids.
Phosphatidylcholine forms a shuttle capable of transporting the active ingredients, protecting them, through the digestive tract and facilitating their absorption and bioavailability in organs and tissues.
Warnings: Do not exceed the recommended dose for daily intake. The product should be used as part of a varied and balanced diet and a healthy lifestyle. Keep out of reach of children under three years of age.